DGL Synergy™, 90 Chew Tabs, Designs for Health

Overview

DGL chewable tablets helps to support digestion and peptic ulcers in a pleasant tasting tablet. Gluten Free Dairy Free Vegetarian Non-GMO

Supports

• Digestion – peptic ulcers, H. pylori
• Anti-Inflammatory

Feature Ingredients

• DGL is the form associated with the greatest clinical efficacy, as it allows for licorice to be released in the stomach and dispersed/absorbed by the gastric mucosa. 
• Deglycyrrhizination prevents adverse effects associated with licorice consumption

Details

DGL Synergy™ is a fast-acting, chewable formula of deglycyrrhizinated licorice (DGL), which offers support for the gastric mucosa. It contains a standardized high-quality form of DGL, the amino acid glycine, and calcium in the form of calcium glycerophosphate.

• Deglycyrrhizinated licorice, or DGL, has been used clinically for decades, primarily for the treatment of peptic ulcers.¹ 
• Licorice has been shown to inhibit several inflammatory enzymes, including both cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX), decreasing the production of several potent inflammatory compounds, including prostaglandin E2, thromboxane B2, and leukotriene B4.
• Importantly, this inhibition is not due to glycyrrhizic acid, the component of licorice which has been removed in DGL, and which is associated with mineralocorticoid excess and hypertension.² 
• Another component of licorice, glabridin, has been shown to prevent lipopolysaccharide (LPS) induced production of inflammatory compounds, including nitric oxide and interleukin-1 beta, whereas glycyrrhizic acid has no effect.
• Clinically, DGL has been shown to have comparable efficacy to cimetidine for both the healing and prevention of ulcer recurrences.³ 
• Additionally, extracts of licorice have been shown to inhibit the adhesion of H. pylori to gastric mucosa, as well as the growth of antibiotic resistant strains, suggesting multiple mechanisms of action for its anti-ulcer benefit.^4,5 The use of chewable tablets appears necessary for DGL’s efficacy, as it allows for distribution and absorption by the gastric mucosa.³

Ingredients

SKU: DGL090-CN : NPN: 80057886

Serving Size: 1 Vegetarian Chew Tab

Servings per Container: 90

Medicinal Ingredients

Allergens

Contains No: Added: artificial colours, preservatives, or sweeteners; dairy, wheat, gluten, animal products, or GMOs.  Suitable for Vegetarians/Vegans.

Recommended Use

Adults 19+:  Take 1 tablet 3 times per day. Chew between meals or 20 minutes before meals. Take a few hours before or after taking other medications.

Designs for Health Advantage 

Higher Standards. Better Results: Designs for Health maintains a strict, no-compromises approach to quality raw material selection. We never cut corners with substandard ingredients. Over 50,000 Doctors Agree that Designs for Health is the physician's choice for top quality professional strength supplements since 1989. Our "Science First" philosophy ensures our products are based on the most recent research and use the highest quality raw ingredients.

Contraindications

Do not use if you are hypersensitive or allergic to any of the ingredients. 

Caution

Consult a health care practitioner prior to use if you are taking any medications or if you have any pre-existing condition including but not limited to: pregnant or breast-feeding. Discontinue 2 weeks prior to any scheduled surgery.

No known drug interactions. Licorice influences the activity of several cytochrome enzymes, and reduces warfarin activity in animal models, likely due to glycyrrhizic acid activity. Thus DGL use should be carefully monitored in these patients.

Side Effect Risks

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance.  Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

Disclaimer

The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.

References

1. Turpie AG, et al. Clinical trial of deglydyrrhizinized liquorice in gastric ulcer. Gut. 1969 Apr;10(4):299-302.
2. Chandrasekaran CV, et al. Dual inhibitory effect of Glycyrrhiza glabra (GutGard™) on COX and LOX products. Phytomedicine. 2011 Feb 15;18(4):278-84.
3. Morgan AG, et al. Comparison between cimetidine and Caved-S in the treatment of gastric ulceration, and subsequent maintenance therapy. Gut. 1982 Jun;23(6):545-51.
4. Wittschier N, et al. Aqueous extracts and polysaccharides from liquorice roots (Glycyrrhiza glabra L.) inhibit adhesion of Helicobacter pylori to human gastric mucosa. J Ethnopharmacol. 2009 Sep 7;125(2):218-23.
5. Fukai T, et al. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 2002 71:1449-63.