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Bio B12 + Folic Acid, 60 Chew Tabs

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High-dose B12 formula with folic acid.


  • Nutrients: vitamin B12
  • Energy: helps to form red blood cells
  • Metabolism: helps the body to metabolize carbohydrates, fats, and proteins.
  • Pregnancy: helps to reduce the risk of neural tube defects when taken daily prior to becoming pregnant and during early pregnancy.3,4

Feature Ingredients 

  • Provides 1000 mcg of vitamin B12 (cyanocobalamin) and 400 mcg of folic acid per dose

Bio B12 + Folic Acid includes a high-dose of vitamin B12 to help support macronutrient metabolism and prevent vitamin B12 deficiency.1

  • Vitamin B12 is an important cofactor for two enzymatic reactions: 1) methylmalonyl-CoA mutase, which helps break down branch chain amino acids and odd numbered fatty acids; 2) methionine synthase, which is needed for methyl transfer reactions, including the folic acid dependent conversion of homocysteine to methionine for protein production.2
  • Daily supplementation with 400 mcg of folic acid during the first trimester helps decrease neural tube defects by approximately 50%.3
  • As folic acid is a methyl group donor, research indicates that neural tube defects may result from impaired methylation.4
  • Similarly, decreases in the availability of vitamin B12 or folic acid lead to the accumulation of homocysteine, which may inhibit methyl transfer reactions.4 Vitamin B12 helps enhance methionine synthesis and increases the ability of folic acid to lower homocysteine levels for normal methyl metabolism.5,6 The vitamin is also required for the methylation of proteins involved in the synthesis and maintenance of myelin, and vitamin deficiencies can result in decreased production of myelin sheath, material needed for normal nervous system function.7,8 As methionine synthase is needed to form red blood cells, deficiencies in vitamin B12 have been associated with the production of abnormally large and irregularly shaped blood cells.7

Serving Size: 1 Vegetarian Chewable Tablets

Servings per Container: 60

Medicinal Ingredients

Each Capsule Contains:

Folate (folic acid)                              400 mcg

Vitamin B12 (cyanocobalamin)        1000 mcg

Non-Medicinal Ingredients

Mannitol, maltodextrin, cellulose, stearic acid, natural cherry flavour, silica, carmine


Contains No Added: artificial colours, preservatives, or sweeteners, dairy, wheat, starch, gluten, yeast, corn, soy or sodium. Suitable for Vegetarians.

Recommended Use 

Adults and Children (4 years+): Chew one tablet daily or as recommended by your healthcare practitioner.

Genestra Advantage 

Genestra delivers professional-grade products that are offered in a variety of formats. Genestra natural health products have been proven safe, effective and reliable for over 30 years, and are backed by clinical evidence. Genestra brings you HMF Forte, HMF Immune, HMF UTI, Digest Plus, Probiotics, D-Mulsion and Super EFA Liquid.


Do not use if you are hypersensitive or allergic to any of the ingredients.


Consult a health care practitioner prior to use if you are taking any medications or if you have any pre-existing condition or symptoms including but not limited to if you are pregnant or breastfeeding. Discontinue 2 weeks prior to any scheduled surgery. 

Side Effect Risks 

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include allergy or intolerance and or digestive symptoms (nausea, vomiting, or diarrhoea). Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. Store in a cool dry area.


The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.  


  1. Allen, LH. Am J Clin Nutr. 2009; 89(suppl): 693S-696S.
  2. Nielsen, MJ, Rasmussen, MR, Andersen, CBF, Nexo, E, Moestrup, SK. Nat. Rev. Gastroenterol. Hepatol. 2012; 9: 345-354.
  3. Osterhues, A, Ali, NS, Michels, KB. Critical Reviews in Food Science and Nutrition. 2013; 53: 1180-1190.
  4. Imbard, A, Benoist, JF, Blom, HJ. Int. J. Environ. Res. Public Health. 2013; 10: 4352-4389.
  5. Fenech, M. Mutation Research. 2012; 733: 21- 33.
  6. Czeizel, AE, Dudàs, I, Vereczkey, A, Bànhidy, F. Nutrients. 2013; 5: 4760-4775.
  7. Briani, C, Dalla Torre, C, Citton, V, Manara, R, Pompanin, S, Binotto, G, Adami, F. Nutrients. 2013; 5: 4521-4539.
  8. Rush, EC, Katre, P, CS Yajnik, CS. European Journal of Clinical Nutrition. 2014; 68: 2-7.