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A formulation targeting the support of healthy estrogen metabolism. DIM is a natural component derived from indole-3-carbinole and cruciferous vegetables.


  • Nutrients: antioxidants
  • Hormones: estrogen metabolism, recurrent breast pain (cyclical mastalgia)

Feature Ingredients 

  • DIM®Enhanced is a microencapsulated form of diindolylmethane (DIM) designed to promote healthy estrogen balance and detoxification.
  • Microencapsulated DIM with Meriva®curcumin, green tea, and Wasabia japonica

DIM® Enhanced is a microencapsulated form of diindolylmethane (DIM) designed to promote healthy estrogen balance.

  • Curcuminoids and green tea extract are also included alongside wasabia.
  • Healthy hormone detoxification is a crucial part of the normal functioning of organs, including the breast.
  • DIM is known to help stimulate natural detoxification enzymes to support healthy estrogen metabolism. As a natural component derived from indole-3-carbinole and cruciferous vegetables, DIM has been shown in clinical research to favour the production of the estrogen metabolite 2-hydroxysterone over the more deleterious 16-hydroxyestrone.
  • DIM can also decrease the severity and duration of recurrent breast pain and promote antioxidant support.
  • Microencapsulated DIM®by BioResponse® is a patented, absorption-enhancing formulation to ensure proper assimilation by the body. It is the only DIM with proven absorption and activity demonstrated in independently performed clinical studies.
  • Polyphenols in green tea, specifically the catechins, provide the primary health promoting benefits associated with green tea consumption. Catechins, most notably epigallocatechin gallate (EGCG), are effective antioxidants and decrease harmful oxidative damage. Similarly, curcuminoids are the naturally occurring bioactive compounds from turmeric.
  • Since curcuminoids exhibit poor absorption when consumed orally, DIM®Enhanced contains a highly bioavailable curcumin complex called MERIVA®. Pharmacokinetic comparison studies have shown MERIVA® to have up to a 20-fold improvement in bioavailability versus the standard 95% turmeric extracts.
  • Wasabia japonica(a member of the cruciferous vegetable family) contains long chain isothiocyanates (ITCs), which are unique to wasabia.

Serving Size: 1 Vegetarian Capsule

Servings per Container: 30

Medicinal Ingredients

Ingredients Per Vegetarian Capsule:

Bioresponse DIM (125 mg) Providing:
DIM (3,3'-Methylenebis-1H-indole)
 31.25 mg 
Camellia sinensis
Extract: 20 : 1 /DHE: 4000  mg
(95.0  %  Polyphenols &
45.0  %  Epigallocatechin 3-gallate)
200 mg
Meriva Providing: Curcuminoids 25 mg
Wasabia japonica rhizome 50 mg


Non-medicinal Ingredients

hypromellose (capsule), disbasic calcium phosphate dihydrate, Cellulose, Silica, Magnesium Stearate, Starch , Vitamin E, Phosphatidylcholine (from sunflower & soy)


Contains No Added: artificial colours, or preservatives. Contains Sunflower and Soy.

Recommended Use 

Adult 19+: Take 1 twice daily or as directed or by a healthcare professional. 

Douglas Advantage 

For over 60 years, Douglas Laboratories has been dedicated to meeting the needs of healthcare professionals and is recognized as a leader in the development of high quality, science-based, innovative nutritional supplements across 12 health functions that support healthy lifestyles. As the industry leader and pioneer in private label solutions, Douglas Laboratories can also help you seamlessly create your own uniquely branded product portfolio to meet the needs of your practice. Discover how Douglas Laboratories can help your patients push their potential of healthier living, today and in the future.


Do not use if you are hypersensitive or allergic to any of the ingredients. Do not use if you are pregnant or breastfeeding. 


Consult a health care practitioner prior to use if you are taking any medications  or if you have any pre-existing condition or symptoms including but not limited to pregnancy, breastfeeding, a liver disorder or symptoms of low estrogen (such as joint pain, mood changes, changes in libido, hot flashes, night sweats, vaginal dryness or irregular menstruations), an iron deficiency, gallstones or bile duct obstruction, stomach ulcers or excess stomach acid, or if you are attempting to conceive. To exclude the diagnosis of a serious cause of hormonal imbalance, consult a health care practitioner prior to use. Discontinue 2 weeks prior to any scheduled surgery. 

Side Effect Risks 

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include allergy or intolerance, weakness, liver trouble (such as abdominal pain, dark urine or jaundice) or symptoms of low estrogen, discontinue use and consult a health care practitioner. Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. Store in a cool dry place.


The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.