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Provides high absorption querectin.
Supports
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Nutrients - quercetin, vitamin C, antioxidants
- Immunity - colds, flu, allergies, sinus
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Health - inflammation, longevity
Feature Ingredients
- EMIQ provides 40 times greater absorption than quercetin
- Provides 167 mg enzymatically modified isoquercitrin (EMIQ) and 50 mg vitamin C per capsule
- Prepared using a natural enzyme process that attaches polysaccharides to convert quercetin into a soluble form
Quercetin, a dietary flavonol known to be one of the most potent plant-derived antioxidants, has multiple biological actions, with anti-inflammatory, anti-thrombotic and vasodilatory benefits in pre-clinical studies.1 However, clinical trials have not consistently matched expected results based upon pre-clinical studies.
- The limiting factor in quercetin’s clinical efficacy appears to be its poor bioavailability. Enzymatically modified isoquercitrin (EMIQ) is a mixture of quercetin monoglucoside and its alpha-oligoglucosides that has been shown to have significantly greater bioavailability than other available forms. In animals, EMIQ was shown to produce a 40 fold increase in Cmax (peak plasma concentration) and an 18-fold increase in the area under the curve compared to quercetin.2 In humans, EMIQ supplementation increased plasma concentrations to a significantly greater degree than other forms,3 including aglycone and isoquercitrin, with randomized placebo-controlled trials documenting improvement in allergic symptoms.4,5 EMIQ has also shown significantly enhanced biological activity especially in animal models of allergy and neoplasia.6
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EMIQ has shown significant effects in improving ocular symptoms of hay fever in doubleblind clinical studies. In one study, 20 subjects with hay fever due to Japanese cedar pollinosis took two capsules daily of 100 mg EMIQ or a placebo for 8 weeks during the pollen season.7 During the entire study period, total ocular score and ocular itching score for the EMIQ group were significantly lower than the placebo group. In another study of hay fever due to Japanese cedar pollinosis, 24 subjects took 100 mg EMIQ or a placebo for 8 weeks, starting 4 weeks prior to the onset of pollen release.8 During the entire study period, ocular symptom and medication scores for the EMIQ group was significantly lower than the placebo group. When limited to the pollen release period, ocular symptom and ocular congestion scores for the EMIQ group were significantly lower than the placebo group. Other scores for the EMIQ group, such as ocular itching scores, lacrimation scores, and ocular congestion scores, all tended to be lower.
Serving Size: 1 Vegetarian Capsule
Servings per Container: 60
Medicinal Ingredient
| Each Vegetarian Capsule Contains: | |
|
EMIQ® (Enzymatically Modified Isoquercitrin) (Providing 50 mg of Highly Absorbable Quercetin) |
167 mg |
| Vitamin C (Calcium Ascorbate) | 50 mg |
Non-Medicinal Ingredients
Microcrystalline cellulose, vegetarian capsule (carbohydrate gum [cellulose], purified water), vegetable grade magnesium stearate (lubricant).
Allergens
Contains No Added: artificial colours, preservatives, or sweeteners; dairy, sugar, starch, wheat, gluten, yeast, soy,egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for Vegetarians/Vegans.
Recommended Use
Adults 19+: 1 capsule, 1–2 times per day, or as directed by a health care practitioner. Consult a health care practitioner for use beyond 8 weeks.
Bioclinic Naturals Advantage
Highly bioavailable ingredients for optimal absorption.
Contraindications
Do not use if you are hypersensitive or allergic to any of the ingredients.
Caution
Consult a health care practitioner prior to use if you are taking any medications, or if you have any pre-existing condition including but not limited to pregnancy, or breastfeeding. Discontinue this product 2 weeks prior to surgery.
No specific contraindications, although safety has not been established during pregnancy and lactation. Patients with impaired renal function should also use with caution.
No specific drug interactions, although theoretically, drugs metabolized by CYP3A4 and/or P-glycoprotein (Pgp) could have altered pharmacokinetics/bioavailability.9
Side Effect Risks
Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance, digestive (nausea, vomiting or diarrhoea). Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Disclaimer
The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.
References
- Erdman JW Jr, Balentine D, Arab L, et al. Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr. 2007 Mar;137(3 Suppl 1):718S-737S.
- Makino T, Shimizu R, Kanemaru M, et al. Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats. Biol Pharm Bull. 2009 Dec;32(12):2034-40.
- Murota K, Matsuda N, Kashino Y, et al. alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans. Arch Biochem Biophys. 2010 Sep 1;501(1):91-7.
- Hirano T, Kawai M, Arimitsu J, et al. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int. 2009 Sep;58(3):373-82.
- Kawai M, Hirano T, Arimitsu J, et al. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol. 2009;149(4):359-68.
- Makino T, Kanemaru M, Okuyama S, et al. Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice. J Nat Med. 2013 Mar 14.
- Kawai M, Hirano T, Arimitsu J, et al. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol. 2009;149(4):359-68.
- Hirano T, Kawai M, Arimitsu J, et al. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int. 2009 Sep;58(3):373-82.
- Hsiu SL, Hou YC, Wang YH, et al. Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Life Sci. 2002 Dec 6;72(3):227-35.
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