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Hormone support for estrogen excess. Estrogen modulator.
Supports
- Nutrients - antioxidants
- Hormone Imbalances - estrogen dominance
- Health - inflammation, cancer, longevity
Feature Ingredients
- IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.
- Additional supportive constituents include: calcium d-glucarate, indole-3-carbinol, green tea extract, tomato extract, broccoli powder, DIM, turmeric, milk thistle extract, and rosemary.
In general, estrogen can be divided into several biochemically distinct hormones: estrone (E1), estradiol (E2), estriol (E3), and 17β-estradiol.1 In premenopausal women, estrogen is enzymatically converted to several specific estrogen metabolites including 2-hydroxyestrone (2-OHE1), 2-hydroxyestradiol (2-OHE2), 4-hydroxyestrone (4-OHE1), 4-hydroxyestradiol (4-OHE2) and 16α-hydroxyestrone (16α-OHE1). Both 16α-OHE1 and 2-OHE have contrasting biological activities at the cellular level with 16α-OHE1 being an estrogen agonist and proliferative, while 2-OHE is an estrogen antagonist and antiproliferative.2
- As such, an increased ratio 2-OHE:16α-OHE1 is associated with a reduced risk of invasive breast cancer risk in premenopausal women.3
- Several natural products found in EstroVantage EM support this latter concept including DIM, and indole 3 carbinol (I3C). A human study has confirmed that daily supplementation with 300 mg of I3C daily for 12 weeks significantly increased the 2-OH-estrone: estriol metabolite ratio without notable adverse events.4
- Other compounds in EstroVantage EM, including
- inhibit beta-glucoronidase activity, allowing for the excretion of estrogen before reabsorption.5 It is estimated that a 4% calcium glucarate supplemented diet inhibits beta-glucuronidase activity by 70%.6
- IGF-1 has a known pathogenic role in cancer, increasing growth of existing cancer cells. Lycopene supplementation decrease IGF-1 by 25%.7
- In a 34 patient randomized controlled trial foods enriched with bioactive compounds, including rosemary extract (Rosemarinus officinalis), were found to be a promising adjuvant therapy in advanced breast cancer patients8
- Green tea polyphenols inhibit the proliferation of breast cancer cells in vivo and in vitro9
- Silymarin can down-regulate gene products involved in the proliferation of tumour cells (cyclin D1, EGFR, COX-2, TGF-beta, IGF-IR), invasion (MMP-9), angiogenesis (VEGF) and metastasis (adhesion molecules)10
- Curcumin inhibits human breast cancer cell growth by mediating certain signalling cascades including the modulation of the NF-κB signalling pathway11
- Sulforaphane can inhibit the expression of estrogen receptor alpha (ERalpha) protein in MCF-7 cells, inhibiting proliferation and down-regulating hormone receptor expression12
- Suitable for vegetarians/vegans
Serving Size: 3 Capsules
Servings per Container: 30
Medicinal Ingredient
| Calcium D-Glucarate (d-Glucaric Acid Calcium Salt) | 75 mg |
| Indole-3-Carbinol (3-Hydroxymethylindole) | 75 mg |
| Green Tea Extract (Camellia sinensis) (leaf) (80% Catechins, 45% EGCG*, <1% Caffeine) | 50 mg |
| Tomato Extract (Lycopersicon esculentum) (fruit) (5% Lycopene) | 50 mg |
| Broccoli Powder (Brassica oleracea var. italica) (aerial) (0.36% Sulforaphane) | 27.5 |
| DIM (3,3’-Diindolylmethane) | 25 mg |
| Turmeric Extract (Curcuma longa) (rhizome) (95% Curcuminoids) | 25 mg |
| Milk Thistle Extract (Silybum marianum) (seed) (50–60% Silymarin) | 25 mg |
| Rosemary 6:1 Extract (Rosmarinus officinalis) (leaf) | 12.5 |
| * Epigallocatechin-3-gallate |
Non-Medicinal Ingredients
Vegetarian capsule (carbohydrate gum [cellulose], purified water), microcrystalline cellulose, vegetable grade magnesium stearate (lubricant), silica.
Allergens
Contains No Added: artificial colours, preservatives, or sweeteners; dairy, sugar, starch, wheat, gluten, yeast, soy,egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for Vegetarians/Vegans.
Recommended Use
Adults 19+: 3 capsules once per day with food or as directed by a health care practitioner. Consult a health care practitioner for use beyond 12 weeks.
Bioclinic Naturals Advantage
Highly bioavailable ingredients for optimal absorption.
Contraindications
Do not use if you are hypersensitive or allergic to any of the ingredients.
Caution
Consult a health care practitioner prior to use if you are taking any medications, or if you have any pre-existing condition including but not limited to pregnancy, or breastfeeding. Discontinue this product 2 weeks prior to surgery.
No specific contraindications, although safety has not been established during pregnancy and lactation. Patients with impaired renal function should also use with caution.
No specific drug interactions, although theoretically, drugs metabolized by CYP3A4 and/or P-glycoprotein (Pgp) could have altered pharmacokinetics/bioavailability.9
Side Effect Risks
Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance, digestive (nausea, vomiting or diarrhoea). Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Disclaimer
The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.
References
- Erdman JW Jr, Balentine D, Arab L, et al. Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC. J Nutr. 2007 Mar;137(3 Suppl 1):718S-737S.
- Makino T, Shimizu R, Kanemaru M, et al. Enzymatically modified isoquercitrin, alpha-oligoglucosyl quercetin 3-O-glucoside, is absorbed more easily than other quercetin glycosides or aglycone after oral administration in rats. Biol Pharm Bull. 2009 Dec;32(12):2034-40.
- Murota K, Matsuda N, Kashino Y, et al. alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans. Arch Biochem Biophys. 2010 Sep 1;501(1):91-7.
- Hirano T, Kawai M, Arimitsu J, et al. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int. 2009 Sep;58(3):373-82.
- Kawai M, Hirano T, Arimitsu J, et al. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol. 2009;149(4):359-68.
- Makino T, Kanemaru M, Okuyama S, et al. Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice. J Nat Med. 2013 Mar 14.
- Kawai M, Hirano T, Arimitsu J, et al. Effect of enzymatically modified isoquercitrin, a flavonoid, on symptoms of Japanese cedar pollinosis: a randomized double-blind placebo-controlled trial. Int Arch Allergy Immunol. 2009;149(4):359-68.
- Hirano T, Kawai M, Arimitsu J, et al. Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis. Allergol Int. 2009 Sep;58(3):373-82.
- Hsiu SL, Hou YC, Wang YH, et al. Quercetin significantly decreased cyclosporin oral bioavailability in pigs and rats. Life Sci. 2002 Dec 6;72(3):227-35.
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