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Melatonin is a naturally occurring antioxidant and hormone that supports sleep. 3 mg strength is optimal for those who require basic sleep support or are trying melatonin for the first time.
Supports
- Nutrients - antioxidant
- Sleep - jet lag, shift work, age-related insomnia, delayed sleep-phase disorder, advanced sleep-phase disorder, and non-24-hour sleep-wake disorder.
- Longevity -Chronic sleep disturbance is a risk factor for premature aging, diabetes, obesity, cardiovascular disease and certain cancers,1
Feature Ingredients
- Sublingual tablets provide fast and superior melatonin absorption, bypassing liver and gastrointestinal metabolism - pharmacokinetic studies indicate that 30 to 60% of an oral dose of melatonin is metabolized via the liver1 and overall gastrointestinal absorption is variable2,3
- Derived from non-animal sources
- Refreshing, natural peppermint flavour
- Non-habit forming
- Sleep is a vital part of health and many of us are not getting enough. The 2002 Canadian Community Health Survey found about 1 in 7 adults has difficulty falling asleep or staying asleep. Insomnia affects 1 in 3 seniors and is 40% more common in women. Changes in sleeping patterns are largely reflective of our circadian rhythms, which are guided by the pineal hormone, melatonin.
- Melatonin is known to decline as we age, which accounts for a number of the sleep changes we see throughout life. Additionally, jet lag and shift work can significantly alter circadian rhythms and thus melatonin secretion.4,5,6
- Melatonin has shown clinical benefit for inducing sleep or adjusting sleep cycles,7 reducing sleep onset latency and improving perceived quality of sleep, without impairing daytime psychomotor performance.8,9
- In fact, supplemental melatonin and bright light therapy are considered standard medical treatment for cases of jet lag, shift work, age-related insomnia, delayed sleep-phase disorder, advanced sleep-phase disorder, and non-24-hour sleep-wake disorder.10 Chronic sleep disturbance is a risk factor for premature aging, diabetes, obesity, cardiovascular disease and certain cancers,11 demonstrating just how important it is to maintain normal melatonin levels to enhance sleep quality.
Serving Size: 1 Sublingual Tablet
Servings per Container: 180
Medicinal Ingredients
| Each Tablet Contains: | |
| Melatonin (vegetarian source) | 3 mg |
Non-Medicinal Ingredients
Lactose monohydrate, microcrystalline cellulose, natural peppermint flavour, croscarmellose sodium, vegetable grade magnesium stearate (lubricant).
Allergens
Contains No Added: artificial colours, preservatives, or sweeteners; starch, wheat, gluten, yeast, soy,egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for Vegetarians/Vegans.
Recommended Use
Adults 19+: Do not drive or use machinery for 5 hours after taking melatonin. Dissolve 1 tablet under the tongue at bedtime once per day or as directed by a health care practitioner. Consult a health care practitioner for use beyond 4 weeks.
Bioclinic Naturals Advantage
Highly bioavailable ingredients for optimal absorption.
Contraindications
Do not use if you are hypersensitive or allergic to any of the ingredients, if you are taking immunosuppressive drugs and/or if you are pregnant or breastfeeding.Do not drive or use machinery for 5 hours after taking melatonin.
Caution
Consult a health care practitioner prior to use if you are taking any medications, or if you have any pre-existing condition. Discontinue this product 2 weeks prior to surgery.
Melatonin may impair glucose utilization and increase insulin resistance in diabetic patients. However, the clinical significance of this effect on diabetics is unknown.12 Contraceptive drugs can increase endogenous melatonin levels. Theoretically, this may increase the effects and adverse effects of oral melatonin use.13 Fluvoxamine significantly inhibits the elimination of melatonin,14 which some researchers believe could be helpful in the treatment of refractive insomnia.15 However, this interaction may also cause excessive unwanted drowsiness and other adverse effects. Melatonin production and release may be inhibited by beta-blockers16 and non-steroidal anti-inflammatory drugs17.
Side Effect Risks
Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance. Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Disclaimer
The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.
References
- Agostini F, Biolo G. Effect of physical activity on glutamine metabolism. Curr Opin Clin Nutr Metab Care. 2010 Jan;13(1):58-64.
- Zuhl M, Dokladny K, Mermier C, et al. The effects of acute oral glutamine supplementation on exercise-induced gastrointestinal permeability and heat shock protein expression in peripheral blood mononuclear cells. Cell Stress Chaperones. 2015 Jan;20(1):85-93.
- Lambertucci AC, Lambertucci RH, Hirabara SM, et al. Glutamine supplementation stimulates protein-synthetic and inhibits protein-degradative signaling pathways in skeletal muscle of diabetic rats. PLoS One. 2012;7(12):e50390.
- Shakibaei M, John T, Schulze-Tanzil G, et al. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem Pharmacol. 2007 May 1;73(9):1434-45.
- Aggarwal BB. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr. 2010 Aug 21;30:173-99.
- Nicol LM, Rowlands DS, Fazakerly R, et al. Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS). Eur J Appl Physiol. 2015 Aug;115(8):1769-77.
- Tanabe Y, Maeda S, Akazawa N, et al. Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. Eur J Appl Physiol. 2015 Sep;115(9):1949-57.
- Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov;19(6):933-9. doi: 10.1007/s00776-014-0633-0.
- Sasaki H, et al. Innovative preparation of curcumin for improved oral bioavailability. Biol Pharm Bull. 2011;34(5):660-5.
- Samocha-Bonet D, Chisholm DJ, et al. Glycemic effects and safety of L-Glutamine supplementation with or without sitagliptin in type 2 diabetes patients-a randomized study. PLoS One. 2014 Nov 20;9(11):e113366.
- Litinski, M., Scheer, F.A., Shea, S.A. (2009). Influence of the circadian system on disease
severity. Sleep Med Clin. 4(2), 143-163. - Cagnacci, A., Arangino, S., Renzi, A., et al. Influence of melatonin administration on glucose
tolerance and insulin sensitivity of postmenopausal women. Clin Endocrinol (Oxf). 54(3),
339-46. - Wright Jr, K.P., Myers, B.L., Plenzler, S.C., et al. (2000). Acute effects of bright light and
caffeine on nighttime melatonin and temperature levels in women taking and not taking oral
contraceptives. Brain Res. 873(2), 310-7. - Hartter, S., Grozinger, M., Weigmann, H., et al. (2000). Increased bioavailability of oral
melatonin after fluvoxamine coadministration. Clin Pharmacol Ther. 67(1), 1-6. - Grozinger, M., Hartter, S., Wang, X., et al. (2000). Fluvoxamine strongly inhibits melatonin
metabolism in a patient with low-amplitude melatonin profile. Arch Gen Psychiatry.
57(8), 812-3. - Stoschitzky, K., Sakotnik, A., Lercher, P., et al. (1999). Influence of beta-blocers
on melatonin release. Eur J Clin Pharmacol. 55, 111-5. - Murphy, P.J., Myers, B.L., Badia, P. (1996). Nonsteroidal anti-inflammatory drugs alter
body temperature and suppress melatonin in humans. Physiol Behav. 59, 133-9.
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