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Melatonin is a naturally occurring antioxidant and hormone that supports sleep. 5 mg strength is optimal for those who require basic sleep support with a time release effect.
Supports
- Nutrients - antioxidant
- Sleep - jet lag, shift work, age-related insomnia, delayed sleep-phase disorder, advanced sleep-phase disorder, and non-24-hour sleep-wake disorder.
- Longevity -Chronic sleep disturbance is a risk factor for premature aging, mood and cognitive function concerns, diabetes, obesity, cardiovascular disease and certain cancers,1
Feature Ingredients
- Clinically shown to improve sleep quality, morning alertness, sleep onset latency and quality of life, with no adverse effects of dependency
- Time release formulation sustains plasma levels for a longer period, enhancing
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Melatonin plays a major role in the circadian regulation of the sleep–wake cycle, and has proven critically important for both initiation and quality of sleep, with supplementation improving sleep in healthy individuals and in those with insomnia, as well as preventing phase shifts due to jet lag or rotating work schedules.1 Time release melatonin improves not only the initiation of sleep, but its longer plasma half-life helps to maintain and improve the quality of sleep.
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Melatonin is particularly effective in older individuals, regardless of endogenous melatonin levels, in both the short and long term, with improvements in sleep quality, morning alertness, sleep onset latency and quality of life, with no relevant adverse effects or dependency.2,3 It has been shown to improve sleep quality in children with diverse sleep complaints, including delayed sleep phase syndrome and impaired sleep maintenance, or other sleep related disorders.4-7
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Melatonin has diverse physiological benefits, including improved bone mineral density in those with osteopenia, reduced depressive symptoms in women undergoing breast cancer surgery, and lowered hepatic enzymes in those with non-alcoholic steatohepatitis.8-10 Time release melatonin has had clinical improvements in mood in those with sleep disturbances, as well as cognitive performance in those with Alzheimer’s disease.11,12
Serving Size: 1 Time Release Tablet
Servings per Container: 60
Medicinal Ingredients
Each Tablet Contains:
Melatonin (Non-Animal Source) 5 mg
Non-Medicinal Ingredients
Dibasic calcium phosphate dihydrate, microcrystalline cellulose, carbohydrate gum [cellulose], vegetable grade magnesium stearate (lubricant).
Allergens
Contains No Added: artificial colours, preservatives, or sweeteners; dairy, starch, sugar, wheat, gluten, yeast, soy,egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for Vegetarians/Vegans.
Recommended Use
Adults 19+: 1–2 tablets per day at or before bedtime, or as directed by a health care practitioner. Do not drive or use machinery for 5 hours after taking melatonin . For use beyond 4 weeks, consult a health care practitioner.
Jet Lag: Take once a day at bedtime after darkness has fallen, while travelling, and at destination until adaptation to the new daily pattern. For occasional short-term use.
Bioclinic Naturals Advantage
Highly bioavailable ingredients for optimal absorption.
Contraindications
Do not use if you are hypersensitive or allergic to any of the ingredients, if you are taking immunosuppressive drugs and/or if you are pregnant or breastfeeding. Do not drive or use machinery for 5 hours after taking melatonin.
Caution
Consult a health care practitioner prior to use if you are taking any medications, or if you have any pre-existing condition. Discontinue this product 2 weeks prior to surgery.
Consumption with alcohol, other medications or natural health products with sedative properties is not recommended. If you are taking one of the following medications, consult a health care practitioner prior to use: anticoagulant, anticonvulsant, blood pressure medications, immunosuppressive medications, sedative, hypnotic or psychotropic medications, or steroids. If you have one of the following conditions, consult a health care practitioner prior to use: asthma, cardiovascular disease, chronic kidney disease, depression, diabetes or hypoglycemia, hormonal disorder, immune system disease, liver disease, migraine, or seizure disorders. If symptoms persist continuously for more than 4 weeks (chronic insomnia) consult a health care practitioner.
Melatonin may impair glucose utilization and increase insulin resistance in diabetic patients. However, the clinical significance of this effect on diabetics is unknown.12 Contraceptive drugs can increase endogenous melatonin levels. Theoretically, this may increase the effects and adverse effects of oral melatonin use.13 Fluvoxamine significantly inhibits the elimination of melatonin,14 which some researchers believe could be helpful in the treatment of refractive insomnia.15 However, this interaction may also cause excessive unwanted drowsiness and other adverse effects. Melatonin production and release may be inhibited by beta-blockers16 and non-steroidal anti-inflammatory drugs17.
Side Effect Risks
Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance. Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Disclaimer
The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.
References
- Costello RB, Lentino CV, Boyd CC, et al. The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutr J. 2014 Nov 7;13:106. doi: 10.1186/1475-2891-13-106.
- Wade AG, Ford I, Crawford G, et al. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Med. 2010 Aug 16;8:51. doi: 10.1186/1741-7015-8-51.
- Wade AG, Ford I, Crawford G, et al. Efficacy of prolonged release melatonin in insomnia patients aged 55-80 years: quality of sleep and next-day alertness outcomes. Curr Med Res Opin. 2007 Oct;23(10):2597-605.
- Wasdell MB, Jan JE, Bomben MM. A randomized, placebo-controlled trial of controlled release melatonin treatment of delayed sleep phase syndrome and impaired sleep maintenance in children with neurodevelopmental disabilities. J Pineal Res. 2008 Jan;44(1):57-64.
- Carr R, Wasdell MB, Hamilton D, et al. Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. J Pineal Res. 2007 Nov;43(4):351-9.
- Chang YS, Lin MH2, Lee JH, et al. Melatonin Supplementation for Children With Atopic Dermatitis and Sleep Disturbance: A Randomized Clinical Trial. JAMA Pediatr. 2016 Jan;170(1):35-42.
- De Leersnyder H, Zisapel N, Laudon M. Prolonged-release melatonin for children with neurodevelopmental disorders. Pediatr Neurol. 2011 Jul;45(1):23-6.
- Amstrup AK, Sikjaer T, Heickendorff L, et al. Melatonin improves bone mineral density at the femoral neck in postmenopausal women with osteopenia: a randomized controlled trial. J Pineal Res. 2015 Sep;59(2):221-9.
- Gonciarz M, Gonciarz Z, Bielanski W, et al. The effects
- of long-term melatonin treatment on plasma liver enzymes levels and plasma concentrations of lipids and melatonin in patients with nonalcoholic steatohepatitis: a pilot study. J Physiol Pharmacol. 2012 Feb;63(1):35-40.
- Hansen MV, Andersen LT, Madsen MT, et al. Effect of melatonin on depressive symptoms and anxiety in patients undergoing breast cancer surgery: a randomized, double-blind, placebo-controlled trial. Breast Cancer Res Treat. 2014 Jun;145(3):683-95.
- Serfaty MA, Osborne D, Buszewicz MJ, et al. A randomized double-blind placebo-controlled trial of treatment as usual plus exogenous slow-release melatonin (6 mg) or placebo for sleep disturbance and depressed mood. Int Clin Psychopharmacol. 2010 May;25(3):132-42.
- Wade AG, Farmer M, Harari G, et al. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial. Clin Interv Aging. 2014 Jun 18;9:947-61.
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