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Methyl Folate L-5-MTHF, 60 Tabs

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Folate as active calcium L-5 methyltetrahydrofolate, Metafolin® 1,000 mcg for improved absorption and utilization.


  • Nutrients: iron
  • Energy: red blood cell formation and function
  • Health: bone, cartilage, teeth and gum maintenance

Feature Ingredients 

  • Methyl Folate supplies 1,000 mcg of biologically active folate per tablet from Metafolin®, a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF).

Methyl Folate supplies 1,000 mcg of biologically active folate per tablet from Metafolin®, a patented, natural form of (6S) 5-methyltetrahydrofolate (5-MTHF).

  • 5-MTHF is the naturally occurring, predominant form of folate commonly found in cells and is essential for overall health.
  • Unlike synthetic folic acid, 5-MTHF can be used directly by the body, without the need for an additional conversion via the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR).
  • In certain populations, the body's ability to convert folic acid to 5-MTHF by use of this enzyme may be compromised due to genetic differences.
  • Metafolin® contains only the S isomer of 5-MTHF and has been shown to be the only form of folate to be able to cross the blood-brain barrier.
  • Folate is a water-soluble essential B vitamin found in many foods, including leafy green vegetables, citrus fruits and beans. Research has established that supplementation with folate before and during the first two months of pregnancy can prevent neural tube defects in the fetus.
  • Additionally, folate plays a key role in red blood cell production and the formation of methionine.

Serving Size: 1 Tablet

Servings per Container: 60

Medicinal Ingredients

Each Tablet Contains:

Folate (calcium L-5 methyltetrahydrofolate/Metafolin®/MD)          1000 mcg

Metafolin® is a registered trademark of Merck KGaA, Darmstadt, Germany

Non-medicinal Ingredients

Cellulose, dicalcium phosphate dihydrate, croscarmellose sodium, magnesium stearate,silica, stearic acid.


Contains No Added: artificial colours, preservatives, or sweeteners.

Recommended Use 

Adults 19+: Take 1 tablet daily, or as directed by your healthcare practitioner.

Douglas Advantage 

For over 60 years, Douglas Laboratories has been dedicated to meeting the needs of healthcare professionals and is recognized as a leader in the development of high quality, science-based, innovative nutritional supplements across 12 health functions that support healthy lifestyles. As the industry leader and pioneer in private label solutions, Douglas Laboratories can also help you seamlessly create your own uniquely branded product portfolio to meet the needs of your practice. Discover how Douglas Laboratories can help your patients push their potential of healthier living, today and in the future.


Do not use if you are hypersensitive or allergic to any of the ingredients.


Consult a health care practitioner prior to use if you are taking any medications, or if you have any pre-existing condition or symptoms including but not limited to if you are pregnant, or breastfeeding. Folate supplementation can mask Vitamin B12 deficiency; consult your healthcare practitioner if you are uncertain whether or not you are taking adequate Vitamin B12. Discontinue 2 weeks prior to any scheduled surgery. 

Side Effect Risks 

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include allergy or intolerance. Some people may experience constipation, diarrhea or vomiting. Sealed for your protection. Do not use if seal is broken. Store in a cool dry place.


The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.