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With Metafolin® L-5-MTHF


  • Nutrients: metabolism, folate (L-5-MTHF), B12 (methylcobalamin), benfotiamine, activated B6
  • Energy: helps form red blood cells

Feature Ingredients 

  • Active folate, B12, B1, and B6

MethylAssist provides activated B vitamins, including Metafolin® L-5- methyltetrahydrofolate (L-5-MTHF), to support nutrient metabolism.

  • Activated B vitamins are particularly important for providing methyl groups involved in the methylation cycle. Methylation involves the transfer of a methyl group (CH3) from one molecule to another.
  • Vitamin B12and folate are required by the enzyme that produces methionine. Folate is provided in this formula as Metafolin®, the naturally occurring, universally metabolized form of folate.
  • Metafolin®is chemically identical to the active folate metabolite, 5-methyltetrahydrofolate (L-5-MTHF). L-5-MTHF is the predominant, naturally occurring form of folate in food. Through bypassing several enzymatic activation steps, it is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations. In addition, these B vitamins also help to form red blood cells.
  • MethylAssist also includes benfotiamine, a synthetic derivative of thiamine reported to have better bioavailability than thiamine itself.
    Metafolin®is a registered trademark of Merck KGaA, Darmstadt, Germany.
    BenfoPure® is a registered trademark of Hamari Chemicals USA, Inc.


SKU : MAS9C-C : NPN: 80047036

Serving Size: 1 Vegetarian Capsule

Servings per Container: 90

Medicinal Ingredients

Each Capsule Contains:


Folate (as Metafolin®, L-5-MTHF) 

1,000 mcg
vitamin B12 (as methylcobalamin)  1,000 mcg
BenfoPure® benfotiamine  75 mg

pyridoxal 5’ phosphate (activated B6) 

25 mg

Non-Medicinal Ingredients

Hypo-allergenic plant fibre (cellulose), vegetarian capsule (cellulose, water).


Contains No Added: artificial colours, preservatives, wheat, gluten, egg, peanuts, coatings and shellacs, GMOs, or magnesium stearate.

Recommended Use 

Adults 19+: Take 1 -3 capsules daily in divided doses, or as directed by a healthcare practitioner.

Pure Encapsulations Advantage 

At Pure Encapsulations, we manufacture hypoallergenic, research-based dietary supplements that are designed to deliver predictable and desired results. We are committed to sourcing pure, premium ingredients and working with experienced healthcare professionals to create safe and effective dietary supplements to help you achieve optimal health. Based on your healthcare practitioner’s medical guidance, we help provide you with the tools and dietary supplements you need to achieve your health and wellness goals. To purchase our products, you must obtain a fulfillment code from your practitioner.


Do not use if you are hypersensitive or allergic to any of the ingredients.


Consult a health care practitioner prior to use if you are taking any medications supplements or if you have any pre-existing condition or symptoms including pregnancy or breastfeeding. Discontinue 2 weeks prior to any scheduled surgery. 

Side Effect Risks 

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include allergy or intolerance.  Some people may experience diarrhoea at doses greater than two capsules per day. Keep out of reach of children. Do not use if seal is broken. Store in a cool, dry place.


The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.