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Nutri Flex Supreme contains 12 synergistic nutrients for joint health. Helps to maintain healthy cartilage and reduces degeneration of joints and surrounding tissues.
Supports
- Joints – Osteoarthritis, Rheumatoid Arthritis, Gout
- Bones & Teeth
- Nutrients – helps in the absorption of calcium and phosphorus
Feature Ingredients
- Glucosamine Sulfate helps to promote flexibility and mobility to the joints.
- Nutri Flex also includes collagen, MSM, bromelain and other natural anti-inflammatory support.
- Supreme formula has added parsley, celery, dandelion, hyaluronic acid, and more.
The health of your joints is impacted by daily wear and tear; injuries; and decades of oxidative stress. The key natural solutions are provided in this all-in-one daily supplement.
- Glucosamine is a well-researched component of glycosaminoglycans and proteoglycans that help trap water in the matrix of cartilage, to promote flexibility and resilience needed to function properly.1 It is an anti-inflammatory, it may support cartilage integrity by modulating synthesis of cartilage structural components by chondrocytes and it plays a crucial role in promoting joint lubrication.2-4
- Collagen is the most abundant protein in mammals and is the main structural protein of connective tissues throughout the body. Hydrolyzed collage helps to reduce the pain associated with osteoarthritis.5-8
- MSM (methylsulfonylmethane) a sulfur-containing compound may reduce inflammation, pain, and the degeneration in joints associated with OA (osteoarthritis).9-11
- Bromelain is a mixture of enzymes found in pineapples that has anti-inflammatory properties. It helps to reduce inflammation, muscle soreness, muscle stiffness, symptoms of OA, and nasal swelling comparable to the commonly used NSAID (non-steroidal anti-inflammatory drug) Voltaren (diclofenac).12,13
- Parsley contains the flavonoid luteolin in which early research suggests has anti-inflammatory properties that may help reduce pain and stiffness in joint health.14
- Celery is not only good to eat as a snack, but research suggests that it may also help to reduce inflammation associated with arthritis.15
- Devil’s claw contains plant compounds called iridoid glycosides, which have been shown to suppress inflammation in test-tube and animal studies.16 It may help reduce pain and inflammation associated with OA and gout.17
- Dandelion is a herbal that helps support liver detoxification.
- Curcumin has potent anti-inflammatory properties. Multiple research studies have found that it may help relieve the pain and symptoms associated with OA.18 In one study, it was found that curcumin may also slow the progression of OA.19
- Boswellia has been found to have potent anti-inflammatory properties.20 It’s biological activity is believed to be linked to the boswellic acid that it contains. Boswellia may also help alleviate asthma, arthritis, and Crohn’s disease.20-22
- Hyaluronic acid is the primary natural polymer compound present in the synovial fluid of joints. It helps to create a viscous, cushioned environment for joint cartilage that helps to prevent friction. In addition to improving joint lubrication, supplemental hyaluronic acid appears to stimulate the body’s generation of new hyaluronic acid, while alleviating pain and inflammation.23-27
- Vitamin D is a fat-soluble vitamin that plays a role in bone health, cell growth, immune function, and fighting inflammation.28,29 In a recent study it was found that the group with consistently sufficient vitamin D status had less tibial cartilage loss and improved physical function compared to those with insufficient levels of vitamin D.30,31
Serving Size: 1 Tablespoon
Servings per Container: 500
Medicinal Ingredients
Each Tablespoon Contains:
| Glucosamine Sulfate (sodium free) | 1500 mg |
| Hydrolyzed Collagen | 1600 mg |
| MSM (Methyl Sulfonyl Methane) | 750 mg |
| Bromelain | 160 mg |
| Parsley | 150 mg |
| Celery | 150 mg |
| Devil's Claw | 150 mg |
| Dandelion | 100 mg |
| Turmeric | 50 mg |
| Boswellia | 10 mg |
| Hyaluronic Acid | 5 mg |
| Vitamin D3 | 25 mcg |
Non-Medicinal Ingredients
Purified water, stevia, potassium sorbate, ascorbic acid, acacia gum, xylitol, xanthan gum, licorice extract, glycerine (vegetable), malic acid, natural caramel colour, natural raspberry flavour
Allergens
Contains No Added: gluten, or GMOs.
Recommended Use
Adults 19+: 1 Tablespoon daily as is or mix with half a glass of water or juice. Avoid taking at bedtime
Naka Advantage
Nutri Flex provides an all-in-one solution for optimal joint health.
Contraindications
Do not use if you are hypersensitive or allergic to any of the ingredients.
Caution
Consult a health care practitioner prior to use if you are taking any medications, or if you have any pre-existing condition including but not limited to: pregnant or breast-feeding. Discontinue 2 weeks prior to any scheduled surgery.
Side Effect Risks
Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance, digestive (bloating, cramping, gas, diarrhoea). Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Disclaimer
The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.
References
- Sanders M, Grundmann O. The use of glucosamine, devil's claw (Harpagophytum procumbens), and acupuncture as complementary and alternative treatments for osteoarthritis. Alternative medicine review : a journal of clinical therapeutic.2011;16(3):228-238.
- Aghazadeh-Habashi A, Jamali F. The glucosamine controversy; a pharmacokinetic issue. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2011;14(2):264-273.
- Reginster JY, Neuprez A, Lecart MP, Sarlet N, Bruyere O. Role of glucosamine in the treatment for osteoarthritis. Rheumatology international. 2012;32(10):2959-2967.
- Fouladbakhsh J. Complementary and alternative modalities to relieve osteoarthritis symptoms. Am J Nurs. 2012;112(3 Suppl 1):S44-51.
- Di Lullo GA, Sweeney SM, Korkko J, Ala-Kokko L, San Antonio JD. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem. 2002;277(6):4223-4231.
- Kumar S, Sugihara F, Suzuki K, Inoue N, Venkateswarathirukumara S. A double-blind, placebo-controlled, randomised, clinical study on the effectiveness of collagen peptide on osteoarthritis. Journal of the science of food and agriculture. 2015;95(4):702-707.
- Zhao W, Tong T, Wang L, et al. Chicken type II collagen induced immune tolerance of mesenteric lymph node lymphocytes by enhancing beta2-adrenergic receptor desensitization in rats with collagen-induced arthritis. International immunopharmacology. 2011;11(1):12-18.
- Cohen ES, Bodmer HC. Cytotoxic T lymphocytes recognize and lyse chondrocytes under inflammatory, but not non-inflammatory conditions. 2003;109(1):8-14.
- Ezaki J, Hashimoto M, Hosokawa Y, Ishimi Y. Assessment of safety and efficacy of methylsulfonylmethane on bone and knee joints in osteoarthritis animal model. Journal of bone and mineral metabolism. 2013;31(1):16-25.
- Debbi EM, Agar G, Fichman G, et al. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011;11:50.
- Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial.Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2006;14(3):286-294.
- NIH: National Center for Complementary and Integrative Health. Bromelain. https://nccih.nih.gov/health/bromelain. Published 2016. Accessed July 9, 2019.
- Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol.2016;35(10):2531-2540.
- Leyva-Lopex N et al, Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases. Int J Mol Sci. 2016 Jun 9;17(6). Pii:E921
- Powanda MC, Whitehouse MW, Rainsford KD, Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities. Prog Drug Res. 2015:70:133-53
- Mncwangi N, et al, Devil's Claw-a review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens. J Ethnopharmacol 2012 Oct 11:143(3):755-71
- Corp B and Pentry N, The role of Western herbal medicine in the treatment of gout, J of Herbal Medicine V3(4) December 2013 157-170
- Nakagawa Y, Mukai S, Yamada S, et al. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014;19(6):933-939.
- Zhang Z, Leong DJ, Xu L, et al. Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis research & therapy. 2016;18(1):128.
- Kizhakkedath R. Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Molecular medicine reports. 2013;8(5):1542-1548.
- Vishal AA, Mishra A, Raychaudhuri SP. A double blind, randomized, placebo controlled clinical study evaluates the early efficacy of aflapin in subjects with osteoarthritis of knee. Int J Med Sci. 2011;8(7):615-622.
- Siddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian journal of pharmaceutical sciences. 2011;73(3):255-261.
- Moskowitz RW. Hyaluronic acid supplementation. Curr Rheumatol Rep. 2000 Dec;2(6):466-71.
- Altman RD. Status of hyaluronan supplementation therapy in osteoarthritis. Curr Rheumatol Rep. 2003 Feb;5(1):7-14.
- Bagga H, Burkhardt D, Sambrook P, March L. Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee. J Rheumatol. 2006 May;33(5):946-50.
- Papakonstantinou E, Roth M, Karakiulakis G. Hyaluronic acid: A key molecule in skin aging. 2012;4(3):253-258.
- Ricci M, Micheloni GM, Berti M, et al. Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritis.Musculoskelet Surg. 2017;101(1):45-49.
- Sanghi D, Mishra A, Sharma AC, et al. Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013;471(11):3556-3562.
- Sanghi D, Mishra A, Sharma AC, et al. Elucidation of dietary risk factors in osteoarthritis knee-a case-control study. J Am Coll Nutr. 2015;34(1):15-20.
- Gao XR, Chen YS, Deng W. The effect of vitamin D supplementation on knee osteoarthritis: A meta-analysis of randomized controlled trials. International journal of surgery (London, England). 2017;46:14-20.
- Zheng S, Jin X, Cicuttini F, et al. Maintaining Vitamin D Sufficiency Is Associated with Improved Structural and Symptomatic Outcomes in Knee Osteoarthritis. Am J Med.2017;130(10):1211-1218.
