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A professional hypoallergenic formula to support migraines when taken prophylactically.


  • Nutrients: folate, vitamin B6, zinc, phenylalanine, antioxidants
  • Migraines
  • Health: sleep, mood, cravings, energy, metabolism of proteins, carbs, and fats, helps form red blood cells, skin, immunity, tissue formation

Feature Ingredients 

  • Active folate (as Metafolin®, L-5-MTHF)
  • Supportive nutrients zinc, phenylalanine, 5-HTP, turmeric, quercetin, and vitamin B6


Helps to reduce the severity and duration of migraine headaches when taken as a prophylactic.

  • Source of the essential amino acid phenylalanine for the maintenance of good health. Provides antioxidants for the maintenance of good health. Factors in the maintenance of good health. Helps the body to metabolize carbohydrates, proteins and fats. Helps to form red blood cells. Helps in connective tissue formation. Helps to maintain healthy skin. Helps to maintain immune function. Helps in tissue formation.

SKU: NOP1C-C ; NPN: 800188

Serving Size: 2 Vegetarian Capsules

Servings per Container: 60

Medicinal Ingredients

Each Serving (2 Capsules) Contains:  
folate (as Metafolin®, L-5-MTHF) 500 mcg
zinc (as zinc picolinate) 10 mg
dl-phenylalanine (free-form) 700 mg
5-hydroxytryptophan 100 mg

Meriva® turmeric phytosome

(turmeric (curcuma longa) extract (root) and phospholipid complex)

(standardized to contain 18% curcuminoids)

250 mg
quercetin 100 mg
pyridoxal 5' phosphate (activated B6) 10 mg

Non-Medicinal Ingredients

Vegetarian capsule (cellulose, water)


Contains No Added: artificial colours, preservatives, wheat, gluten, egg, peanuts, coatings and shellacs, GMOs, or magnesium stearate. Contains soy.

Recommended Use 

Adults 19+: Take 2-4 capsules daily, in divided doses between meals. Consult a healthcare practitioner for use beyond 6 months.

Pure Encapsulations Advantage 

At Pure Encapsulations, we manufacture hypoallergenic, research-based dietary supplements that are designed to deliver predictable and desired results. We are committed to sourcing pure, premium ingredients and working with experienced healthcare professionals to create safe and effective dietary supplements to help you achieve optimal health. Based on your healthcare practitioner’s medical guidance, we help provide you with the tools and dietary supplements you need to achieve your health and wellness goals. To purchase our products, you must obtain a fulfillment code from your practitioner.


Do not use if you are hypersensitive or allergic to any of the ingredients, pregnant or breastfeeding. Do not use if you have scleroderma, tardive disyinesia or phenylketonuria or if you are taking Levodopa, a medication used to treat Parkinson's disease.


Consult a health care practitioner prior to use if you are taking any *medications or if you have any pre-existing condition or symptoms. Discontinue 2 weeks prior to any scheduled surgery.  

*Currently known common cautions & interactions with product include:

  • Health: Gallstones or bile duct obstruction, stomach ulcer or excess stomach acid
  • Antiplatelets, blood thinners, and antidepressants or other anti-psychotic medications, or if you are following a low protein diet.
  • Folic acid supplementation may mask a B12 deficiency; ask your healthcare practitioner if you are taking sufficient B12.
  • Serotinergics: These may include, but are not limited to, L-tryptophan, S-adenosylmethionine (SAMe), St. John's wort, antidepressants, pain killers, over the counter cough and cold medication, anti-nausea medication and anti-migraine medication.

Note – This list is not complete, as all possible interactions are not listed.  Other drugs may interact with this product, including prescription and over-the-counter medicines, vitamins, and herbal products.

Side Effect Risks 

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include allergy or intolerance, diarrhea, nausea, vomiting and abdominal pain or drowsiness. Exercise caution if operating heavy machinery, driving a motor vehicle or involved in activities requiring mental alertness. Discontinue use and consult a healthcare practitioner if you show signs of weakness, oral ulcers, or abdominal pain accompanied by severe muscle pain or if you experience skin changes. Do not use if seal is broken. Store in a cool, dry place.


The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.