Nrf2 is a three-ingredient formula designed to support antioxidant defences.

• Cruciferous vegetables of the brassica family, such as broccoli, have long been recognized for their ability to support antioxidant activity, thereby maintaining healthy cells and tissues. They provide a source of the bioactive constituent sulforaphane, one of the most powerful activators of phase II enzyme function in the liver, protecting tissues from oxidative stress and reactive substances.        
• Sulforaphane and resveratrol promote the activity of nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that supports robust, long-lasting expression of numerous genes responsible for protection against oxidative stress. Nrf2 also supports the biosynthesis of glutathione, a vital component of cellular antioxidant systems.                                                                                    
• The highest concentration of glutathione is found in the liver, where it offers antioxidant support and protects tissue from reactive species produced during detoxification. This formula contains Setria^®glutathione, the only brand of glutathione with research showing absorption. In a randomized clinical trial, supplementation with 250 mg of Setria^® glutathione per day increased glutathione levels in the blood after one, three and six months. Setria^® glutathione also showed support for antioxidant defences, indicated by decreases in the oxidized-to-reduced-glutathione ratio in whole blood after six months.