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SAMe has shown results for osteoarthritis comparable to NSAIDs and may increase cartilage. Vegetarian/Vegan friendly.
Supports
- Osteoarthritis
- Brain & Mood - neurodegenerative disease, depression
- Liver Disease
Feature Ingredients
- Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity12
- Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form
- Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption
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Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations and sourced from the highest quality Italian Isoactive SAMe available on the market
S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways.
- Well-recognized as a unique methyl donor for numerous biological reactions, including DNA methylation, it also links methylation to polyamine synthesis (necessary for cell survival and growth), and trans sulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis.1,2 Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation and apoptosis.3,4
- Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease.5
- For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders.6,7
- SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib.8,9 Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics.10
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Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.11
Service Size: 1 Enteric Coated Tablet
Servings per Container: 30
Medicinal Ingredients
Each Enteric Coated Tablet Contains:
S-Adenosyl-L-Methionine (SAMe) 200 mg
Non-Medicinal Ingredients
Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, talc, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides, yellow iron oxide), glyceryl behenate, vegetable grade magnesium stearate (lubricant), silica, sodium starch glycolate.
Allergens
Contains No Added: artificial colours, preservatives, or sweeteners; dairy, sugar, wheat, gluten, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs. Suitable for Vegetarians/Vegans.
Recommended Use
Adults 19+: SAMe should always be taken on an empty stomach.
- For mood balance: 1–4 tablets 2 times per day or as directed by a health care practitioner.
- For osteoarthritic pain: 1–3 tablets 2 times per day or as directed by a health care practitioner. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.
Bioclinic Naturals Advantage
Highly bioavailable ingredients for optimal absorption.
Contraindications
Do not use if you are hypersensitive or allergic to any of the ingredients, pregnant, or breastfeeding. Not recommended for children.
Caution
Consult a health care practitioner prior to use if you are taking any medications (especially antidepressants, hepatotoxic drugs or monoamine oxidase (MAO) inhibitors, consult a health care practitioner prior to taking SAMe in place of or in addition to those medications) or if you have any pre-existing condition. Discontinue this product 2 weeks prior to surgery.
Do not take at night as SAMe may cause anxiety, restlessness and insomnia. People with bipolar disorder (manic-depressive illness) should not use SAMe unless under medical supervision.
Deficiency of vitamins B6, B12, and other methyl donors may exacerbate SAMe deficiency. Theoretically may have additive serotonergic effects when used with antidepressants, but this has not been observed clinically, and when used simultaneously, no increase in adverse effects were noted compared to placebo.6
Side Effect Risks
Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance or mild gastrointestinal upsets (such as stomach pain, nausea, diarrhea, flatulence), anxiety, hyperactive muscle movement, insomnia and hypomania. When these side effects occur they often diminish with time or resolve with lower doses or cessation of use. There are no documented cases of allergies to SAMe. Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Disclaimer
The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.
References
- Park LK, et al. Nutritional influences on epigenetics and age-related disease. Proc Nutr Soc. 2012 Feb;71(1):75-83.
- Martínez-López N, et al. S-adenosylmethionine and proliferation: new pathways, new targets. Biochem Soc Trans. 2008 Oct;36(Pt 5):848-52.
- Finkelstein JD. Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine. Clin Chem Lab Med. 2007;45(12):1694-9.
- Lu SC, et al. S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J Gastroenterol Hepatol. 2008 Mar;23 Suppl 1:S73-7.
- Bottiglieri T. S-Adenosyl-L-methionine (SAMe): from the bench to the bedside-molecular basis of a pleiotrophic molecule. Am J Clin Nutr. 2002 Nov;76(5):1151S-7S.
- Papakostas GI, et al. S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial. Am J Psychiatry. 2010 Aug;167(8):942-8.
- Williams AL, et al. S-adenosylmethionine (SAMe) as treatment for depression: a systematic review. Clin Invest Med. 2005 Jun;28(3):132-9.
- Kim J, et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther. 2009 Dec;31(12):2860-72.
- Najm WI, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6.
- Hosea Blewett HJ. Exploring the mechanisms behind S-adenosylmethionine (SAMe) in the treatment of osteoarthritis. Crit Rev Food Sci Nutr. 2008 May;48(5):458-63.
- Shea TB, et al. S-adenosyl methionine: a natural therapeutic agent effective against multiple hallmarks and risk factors associated with Alzheimer’s disease. J Alzheimers Dis. 2008 Feb;13(1):67-70.
- Tchantchou F, et al. S-adenosylmethionine mediates glutathione efficacy by increasing glutathione S-transferase activity: implications for S-adenosyl methionine as a neuroprotective dietary supplement. J Alzheimers Dis. 2008 Jul;14(3):323.
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