Shopping Cart


Your shopping bag is empty

Go to the shop

A professional hypoallergenic vegan formula to support joint health. Suitable for Vegetarians and Vegans.


  • Pain & Inflammation: joints
  • Mood

Feature Ingredients 

  • SAMe (S-adenosylmethionine) is found in all living cells and functions as a methyl donor
  • It helps to balance hormones, neurotransmitters, nucleic acids, phospholipids and proteins


SAMe (S-adenosylmethionine) is a metabolite present in all living cells.

  • It functions as a donor of methyl groups in over 100 different reactions and contributes to the synthesis, activation and/or metabolism of hormones, neurotransmitters, nucleic acids, phospholipids, and proteins.
  • Methyl groups act as a signal throughout the body, regulating genetic expression and cellular function.
  • SAMe also promotes healthy mood balance, as indicated in over 40 clinical studies. In a meta-analysis involving 25 controlled trials and 791 individuals, SAMe offered statistically significant support for positive mood, believed to be due to its support for neurotransmitter monoamine synthesis and function, including dopamine and serotonin.
  • It also promotes healthy protein turnover and maintains healthy phospholipid methylation to support phosphatidylcholine production and cellular membrane integrity and fluidity.
  • Studies suggest it supports joint flexibility and comfort in individuals with osteoarthritis as well. In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function. It is believed to relieve osteoarthritis pain by supporting proteoglycan synthesis, as well as helping to stabilize and protect the proteoglycans

SKU: SAM6C-C ; NPN: 80066783

Serving Size: 1 Vegetarian Capsule

Servings per Container: Approximately 60

Medicinal Ingredients

Each Capsule Contains:

SAMe (from S-Adenosyl-L-methionine disulfate tosylate)

200 mg

Non-Medicinal Ingredients 

Vegetarian capsule (hypromellose, water), hypoallergenic plant cellulose, calcium oxide, ascorbyl palmitate, calcium chloride.


Contains No Added: artificial colours, preservatives, dairy, wheat, gluten, egg, peanuts, coatings and shellacs, GMOs, magnesium stearate or animal products.

Recommended Use 

Adults 19+: Take For healthy mood balance, take 2 capsules 1-3 times daily. For osteoarthritic pain, take 2 capsules 3 times daily. Take in divided doses, between meals, or as directed by a healthcare practitioner. For osteoarthritic pain, use for a minimum of 8 weeks to see beneficial effects. Consult a healthcare practitioner for use beyond 12 weeks.

Pure Encapsulations Advantage 

At Pure Encapsulations, we manufacture hypoallergenic, research-based dietary supplements that are designed to deliver predictable and desired results. We are committed to sourcing pure, premium ingredients and working with experienced healthcare professionals to create safe and effective dietary supplements to help you achieve optimal health. Based on your healthcare practitioner’s medical guidance, we help provide you with the tools and dietary supplements you need to achieve your health and wellness goals. To purchase our products, you must obtain a fulfillment code from your practitioner.


Do not use if you are hypersensitive or allergic to any of the ingredients, pregnant or breastfeeding. Do not use if you have been diagnosed with bipolar disorder.


Consult a health care practitioner prior to use if you are taking any *medications or if you have any pre-existing condition or symptoms. Discontinue 2 weeks prior to any scheduled surgery.  

*Currently known common cautions & interactions with product include:

  • Antidepressants
  • Hepatoxic Drugs
  • Monoamine Oxidase (MAO) Inhibitors

Note – This list is not complete, as all possible interactions are not listed.  Other drugs may interact with this product, including prescription and over-the-counter medicines, vitamins, and herbal products.

Side Effect Risks 

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include allergy or intolerance or mild digestive discomfort. Do not take at night, as the product may cause anxiety, restlessness and insomnia. Some people may experience anxiety, restlessness, insomnia, hyperactive muscle movement, and hypomania, in which case discontinue use and consult a health care practitioner. Do not use if seal is broken. Store in a cool, dry place.


The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.