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Three forms of active B12 (Methylcobalamin, Hydroxocobalamin and Adenosylcobalamin) that are bioavailable. are active sources of vitamin B12, each form with its own unique benefits. When combined, they quickly help replenish any Vitamin B12 deficiency in the body and assist it in metabolizing carbohydrates, fats and proteins. They also help in the formation of red blood cells.


  • Nutrients: Vitamin B12 Deficiency, Malabsorption issues, High risk groups
  • Energy: Metabolism of carbs, fats and proteins
  • RBC: Formation of red blood cells (RBC)

Feature Ingredients

  • Methylcobalamin: is involved in methylation, RBC formation, neurotransmitter and DNA synthesis, and homocysteine recycling, which is important for heart health.
  • Adenosylcobalamin: is important for energy production and to maintain a healthy nervous system.
  • Hydroxocobalamin: acts as a precursor to both the above forms (providing long lasting reserves of B12) and has independent detoxifying actions.

Combines three different forms of vitamin B12

  • Combines three different forms of vitamin B12: hydroxycobalamin, adenosylcobalamin and methylcobalamin
  • High dose of bioavailable and active forms of B12
  • Clean sourcing from Europe

AOR’s Tri B12 Synergy is a combination of three independent and active forms of Vitamin B12. Methylcobalamin, Hydroxocobalamin and Adenosylcobalamin are three distinct cobalamin factors, each with their own unique benefits. When taken together, they provide an appropriate dose of bioavailable and active forms of B12 for comprehensive support in replenishing a deficiency. Vitamin B12 deficiencies can be caused by poor diet, impaired microbiota, or malabsorption, which is caused by diseases such as Crohn’s or Celiac or use of proton pump inhibitors such as antacids. Populations at particular risk include the elderly, vegans, smokers, chronic antibiotic use and even genetic factors. AOR has sourced its ingredients from European suppliers certified under the “Green Chemistry” certification system.

Vitamin B12 is used as a co-factor in enzymatic processes, which facilitate reactions in the body, like a key turning on a car ignition. Each form of cobalamin – methyl, hydroxyl, adenosyl – is vital to different cellular processes. Because in their absence key physiologic processes are compromised, a deficiency in B12 may cause a variety of symptoms over time, from fatigue to increased cardiovascular risks, poor balance, and cognitive changes or depression.

Methylcobalamin is involved in the critical metabolic process called methylation, as well as the production of red blood cells, neurotransmitter and DNA synthesis, and homocysteine recycling, which is important for heart health.

Adenosylcobalamin is active within the mitochondria (the powerhouse) of cells to support metabolic function, including carbohydrate and fat metabolism, energy production and to maintain a healthy nervous system.

Hydroxocobalamin acts as a precursor to both the above forms and has independent detoxifying actions. It is also bound to the body’s own transport molecules and serves as storage for later conversion, ensuring a longer lasting supply.

AOR Advantage

  • AOR’s Tri B12 Synergy presents vitamin B12 in its three most active and bioavailable forms. AOR’s ingredients are environmentally-certified pursuant to the “Green Chemistry” certification system.

SKU: AOR04412  : NPN: 80084062

Serving Size: 1 Lozenge

Servings per Container: 60 Lozenges (60 Daily Servings of 1 Per Day)

Medicinal Ingredients

Per Lozenge

Vitamin B12 5 mg

·       MecobalActive 3.5 mg

·       Hydroxocobalamin 1mg

·       Adenosylcobalamin 500 mcg

Non-medicinal Ingredients: Hydroxypropyl cellulose, ascorbyl palmitate, tapioca syrup, xylitol, microcrystalline cellulose and distilled water.


AOR™ guarantees that all ingredients have been declared on the label. Contains no wheat, gluten, nuts, peanuts, sesame seeds, sulphites, mustard, soy, dairy, eggs, fish, shellfish or any animal by-product.

Recommended Use

Adults 19+:  Dissolve one lozenge under the tongue first thing in the morning, or as directed by a qualified health care practitioner.

AOR Advantage 

AOR puts pharmaceutical principles into practice to create the most effective products with the highest quality raw materials. Our processes allow us to ensure potency, purity and traceability from plant to product, giving our customers the certainty that they are always getting the same, effective formulation. We introduce and implement the latest testing strategies as part of our quality assurance process because we believe that it’s not about checking boxes, but how the boxes are checked that is important.


Do not use if you are hypersensitive or allergic to any of the ingredients. 


Consult a health care practitioner prior to use if you are taking any medications or if you have any pre-existing condition. Consult a health care practitioner for use beyond four months. If you are pregnant or breastfeeding, consult a health care practitioner prior to use. Discontinue 2 weeks prior to any scheduled surgery.

Side Effect Risks

Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance.  Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.


The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.

Research Based Facts

In a review on the several forms of vitamin B12, authors Thakkar and Billa (2015) state that both methylcobalamin and adenosylcobalamin are essential with their own distinct functions. They concluded that it would be more beneficial to treat a vitamin B12 deficiency with a combination of methylcobalamin and adenosylcobalamin or hydroxocobalamin (or cyanocobalamin). As well, oral supplementation (ie. tablet, capsule or liquid) has been shown to be as effective as an intramuscular injection for treating a B12 deficiency.

In a 2016 review by Rizzo et al., the authors describe the unique function(s) of each form of cobalamin: Cyanocobalamin and hydroxycobalamin are provitamin forms of B12 that require activation by methylcobalamin or adenosylcobalamin. Adenosylcobalamin works within the mitochondria of cells and when it becomes deficient, this can lead to disrupted communication between nerve cells. Methylcobalamin is responsible for recycling and reducing levels of homocysteine (a marker of cardiovascular disease). The authors also noted that in cases of genetic mutations (also called “polymorphisms”), alternative forms of cobalamin such as methylcobalamin and hydroxycobalamin could improve the effectiveness of supplementation in vegetarians, who are at risk of a B12 deficiency.

A prospective observational study tested the efficacy of using methylcobalamin B12 to treat anemia in children. In this study 28 children with macrocytic anemia (a form of anemia where red blood cells are larger than normal, due to either a vitamin B12 or folate deficiency) were supplemented with methylcobalamin for one month. At the end of the treatment period there was a significant increase in hemoglobin levels, and a significant improvement (decrease) in red blood cell size. Researchers also noted significant improvements in platelet counts and vitamin.