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Vitamin D3 (cholecalciferol) likely more effective at restoring blood levels than D2 form (ergocalciferol).
Supports
- Nutrients: Vitamin D promoting the absorption of calcium and phosphorus
- Bone & Teeth:
- Immunity & Health: Colds, Flu, Longevity
Feature Ingredients
- Vitamin D-helps to support bone health, immunity, preserve youthful cognitive function, helps maintain already-healthy blood pressure, encourages a healthy inflammatory response and promotes endothelial function.1-5
Vitamin D, also known as the “sunshine vitamin” is an essential vitamin that plays many important roles in the proper functioning of the body. Though classified as a vitamin, vitamin D is actually a key regulatory hormone for calcium and bone metabolism. vitamin D has many other roles in the body, including modulation of cell growth, neuromuscular and immune function.
Bone & Teeth - Adequate vitamin D intake is important for ensuring normal calcium absorption and maintaining proper calcium plasma levels. Thus, vitamin D has a critical role in the development and maintenance of bones and teeth.6 Studies have shown that supplementation with high doses of vitamin D maximizes bone health in adults and may decrease the risk of fractures in the elderly.6
Inflammation – Vitamin D has been found to reduce Interleukin-6 (IL-6) an inflammatory cytokine. High levels of IL-6 have been found to be linked to several types of cancer and individuals with excess weight.7,8
Stroke Recovery – Vitamin D deficiency is also linked to stroke. Studies show that those with optimal vitamin D levels decrease their stroke risk and reduce the odds of permanent disability in the event of a stroke.9 A recent study showed that in those individuals recovering from stroke for each 25 nmol/L decrement in vitamin D, the odds of a poor 90-day post-stroke function outcome doubled.9 Another recent study found that those individuals with a minimally adequate vitamin D level of 75 nmol/L (30 ng/mL) or above showed a 90% improvement in functional outcomes vs those who were severely deficient (< 25 nmol/L or 10 ng/mL).10
Diabetes - Vitamin D helps to support the optimal health of beta cells that are the insulin-producing cells in the pancreas.11-13 Insufficient insulin leads to high circulating glucose blood levels or insulin-dependent diabetes that contribute to a long list of deadly disorders that include heart disease,14Alzheimer’s,15 and cancer.16
Mood – Several studies have shown that women who have higher levels of vitamin D while pregnant have a lower incidence of children who develop different psychiatric disorders and ADHD.17,18
Cancer, Cardiovascular Disease and Inflammation – Higher blood levels of vitamin D have been found to be inversely related to cancer, vascular disease and chronic inflammation.19-28
Immunity - Scientists have identified reduced vitamin D levels in winter months as a prime contributor to higher levels of colds, flu, and respiratory infections.29,30
MS - Lower vitamin D levels are associated with an increased risk for the autoimmune disease MS, and more than 90% of people with MS have deficient vitamin D levels.31
Longevity – Compelling research has demonstrated that vitamin D blood levels in the range of 125 to 200 nmol/L or 50-80 ng/mL are associated with increased longevity and a lower risk of common diseases.1-32 Some of the most impressive research discovered on vitamin Dhas been on ICU (intensive care unit) patients. The New England Journal of Medicine first reported in 2009 a striking 45% mortality (death) rate in vitamin D-deficient ICU patients compared to only a 16% mortality rate insufficient vitamin D patients. This study showed that vitamin D deficiency results in almost 3-times more patients dying in the ICU.32
Experts believe that in order to prevent many of the age-related diseases, people should maintain a vitamin D blood level between 125 to 150 nmol/L (potentially up to 200 nmol/L ) or 50-80 ng/mL.33-35
Serving Size: 1 Cap
Servings per Container: 90
Medicinal Ingredients
Vitamin D3 (Cholecalciferol) 1,000 IU (25 mcg)
Non-Medicinal Ingredients
Hypromellose (derived from cellulose) capsule, L-Leucine, Silicon Dioxide, Cellulose, Vitamin E
Allergens
Contains No Added: dairy, corn, gluten, yeast, salt, gluten, artificial colouring, artificial preservatives, artificial sweeteners, or GMOs.
Recommended Use
Adults 19+: Take1 soft gel daily or as directed by a health care practitioner.
Thorne Advantage
Mission: To redefine what it means to be well and to continue to push the limits of human potential.
Our belief is that good health can always be made better. Because no one should be limited by a definition of health that's anything less than optimal.
Finding out what your body needs is only half the solution. Giving it to you is the other half. We offer personal at-home tests to help understand your health and supplements to unlock your full potential.
Contraindications
Do not use if you are hypersensitive or allergic to any of the ingredients. Do not use more than the recommended dose if pregnant or breastfeeding.
Caution
Consult a health care practitioner prior to use if you are taking any medications, or if you have any pre-existing condition including but not limited to: autoimmune disorder, sarcoidosis, lymphoma, tuberculosis, hypercalcemia or renal impairment. May increase the risk for hypercalcemia when taken with a thiazide medication (diuretic).36 Vitamin D may improve insulin sensitivity and lower blood pressure, requiring a reduction in dosage of hypertension and/or diabetic medications. Discontinue 2 weeks prior to any scheduled surgery.
Side Effect Risks
Discontinue use and consult a healthcare practitioner if symptoms persist, worsen or you develop any reactions which may include: allergy or intolerance or digestive (stomach upset).
Keep out of reach of children. Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.
Disclaimer
The information and product descriptions that appear on this website are for information and educational purposes only and are not intended to provide or replace medical advice to individuals from qualified health care professionals. Consult your physician if you have any health concerns, and before initiating any new dietary, exercise, supplements or other lifestyle changes.
References
Reinhold Vieth, Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety1,2, American Journal of Clinical Nutrition, Vol. 69, No. 5, 842-856, May 1999, (http://www.ajcn.org/cgi/content/full/69/5/842)
Robert P Heaney, Lessons for nutritional science from vitamin D1,2, American Journal of Clinical Nutrition, Vol. 69, No. 5, 825-826, May 1999. (http://www.ajcn.org/cgi/content/full/69/5/825)
Clara Felix, The Felix Letter, Nos. 105 & 106, 1999, Catching the Good Rays
Krispin Sullivan, C.N., personal communication, June 2000 (see http://www.krispin.com)
Bill Sardi, Vitamin D Is For Cancer Defense, Nutrition Science News, March 2000, (http://exchange.healthwell.com/nutritionsciencenews/nsn_Backs/Mar_00/vitamind.cfm)
Laird E, et al, Vitamin D and Bone Health; Potential Mechanisms, Nutrients 2010 Jul; 2(7):693-724
Guo Y, Xu F, Lu T, et al. Interleukin-6 signaling pathway in targeted therapy for cancer. Cancer Treat Rev. 2012;38(7):904-10.
Eder K, Baffy N, Falus A, et al. The major inflammatory mediator interleukin-6 and obesity. Inflamm Res. 2009;58(11):727-36.
Turetsky A, Goddeau RP, Jr., Henninger N. Low serum vitamin D is independently associated with larger lesion volumes afterischemic stroke. J Stroke Cerebrovasc Dis. 2015;24(7):1555-63.
Park KY, Chung PW, Kim YB, et al. Serum vitamin D status as a predictor of prognosis in patients with acute ischemic stroke. Cerebrovasc Dis. 2015;40(1-2):73-80.
Talaei A, Mohamadi M, Adgi Z. The effect of vitamin D on insulin resistance in patients with type 2 diabetes. Diabetol Metab Syndr. 2013;5(1):8.
Oh YS, Jun HS. Role of bioactive food components in diabetes prevention: effects on Beta-cell function and preservation. Nutr Metab Insights. 2014;7:51-9.
Yang Z, Liu F, Qu H, et al. 1, 25(OH)2D3 protects beta cell against high glucose-induced apoptosis through mTOR suppressing. Mol Cell Endocrinol. 2015;414:111-9.
Hartog JW, Voors AA, Schalkwijk CG, et al. Clinical and prognostic value of advanced glycation end-products in chronic heart failure. Eur Heart J. 2007;28(23):2879-85.
Xu W, Qiu C, Winblad B, et al. The effect of borderline diabetes on the risk of dementia and Alzheimer’s disease. Diabetes. 2007;56(1):211-6.
Noto H, Osame K, Sasazuki T, et al. Substantially increased risk of cancer in patients with diabetes mellitus: a systematic review and meta-analysis of epidemiologic evidence in Japan. J Diabetes Complications. 2010;24(5):345-53.
McGrath J. Does ‘imprinting’ with low prenatal vitamin D contribute to the risk of various adult disorders? Med Hypotheses. 2001;56(3):367-71.
Morales E, Julvez J, Torrent M, et al. Vitamin D in pregnancy and attention deficit hyperactivity disorder-like symptoms in childhood. Epidemiology. 2015;26(4):458-65.
Wu K, Feskanich D, Fuchs CS, et al. A nested case control study of plasma 25-hydroxyvitamin D concentrations and risk of colorectal cancer. J Natl Cancer Inst. 2007;99(14):1120-9.
Edlich R, Mason SS, Chase ME, et al. Scientific documentation of the relationship of vitamin D deficiency and the development of cancer. J Environ Pathol Toxicol Oncol. 2009;28(2):133-41.
Garland CF, Gorham ED, Mohr SB, et al. Vitamin D for cancer prevention: global perspective. Ann Epidemiol. 2009;19(7):468-83.
Giovannucci E, Liu Y, Hollis BW, et al. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168(11):1174-80.
Dobnig H, Pilz S, Scharnagl H, et al. Independent association of low serum 25-hydroxyvitamin d and 1,25-dihydroxyvitamin d levels with all-cause and cardiovascular mortality. Arch Intern Med. 2008;168(12):1340-9.
Szabo B, Merkely B, Takacs I. The role of vitamin D in the development of cardiac failure. Orv Hetil. 2009;150(30):1397-402.
Gouni-Berthold I, Krone W, Berthold HK. Vitamin D and cardiovascular disease. Curr Vasc Pharmacol. 2009;7(3):414-22.
Suzuki Y, Ichiyama T, Ohsaki A, et al. Anti-inflammatory effect of 1alpha,25-dihydroxyvitamin D(3) in human coronary arterial endothelial cells: Implication for the treatment of Kawasaki disease. J Steroid Biochem Mol Biol. 2009;113(1-2):134-8.
Dietrich T, Nunn M, Dawson-Hughes B, et al. Association between serum concentrations of 25-hydroxyvitamin D and gingival inflammation. Am J Clin Nutr. 2005;82(3):575-80.
Xia JB, Wang CZ, Ma JX, et al. Immunoregulatory role of 1, 25-dihydroxyvitamin D(3)-treated dendritic cells in allergic airway inflammation. Zhonghua Yi Xue Za Zhi. 2009;89(8):514-8.
Camargo CA Jr, Ganmaa D, Frazier AL, et al. Randomized trial of vitamin d supplementation and risk of acute respiratory infection in mongolia. Pediatrics. 2012 Sep;130(3):e561-7.
Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr. 2010 May;91(5):1255-60.
Mokry LE, Ross S, Ahmad OS, et al. Vitamin D and risk of multiple sclerosis: a mendelian randomization study. PLoS Med. 2015;12(8):e1001866.
Lee P, Eisman JA, Center JR. Vitamin D deficiency in critically ill patients. New Engl J Med. 2009;360(18):1912-4.
Bischoff-Ferrari HA, Optimal serum 25-hydroxyvitamin D levels for multiple health outcomes. Adv Exp Med Biol. 2008; 624:55-71
Available at: https://www.lifeextension.com/magazine/2010/1/startling-findings-about-vitamin-d-levels-in-life-extension-members/page-01. Accessed March 25, 2020
https://www.mercola.com/article/vitamin-d-resources.htm, Accessed March 25,2020
Boulard JC, Hanslik T, Alterescu R, Baglin A. [Symptomatic hypercalcemia after vitamin D-thiazide diuretics combination. Two cases in elderly women]. Presse Med. 1994 Jan 22;23(2):96.
